Live imaging of tumor initiation in zebrafish larvae reveals a trophic role for leukocyte-derived PGE₂.

ABSTRACT: Epidemiology studies and clinical trials have suggested that the use of non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, can significantly reduce the incidence of and mortality associated with many cancers, and upregulation of the COX2-PGE(2) pathway in tumor microenvironments might drive several aspects of cancer progression. For these reasons, the mechanisms linking COX blockade and cancer prevention have long been an area of active investigation. During carcinogenesis, COX-2 is expressed both by malignant epithelial cells and by tumor-associated stromal cells, including macrophages, but the observation that NSAIDs are most effective in cancer prevention in APC(min/+) mice if the mice are treated from conception suggests that the COX-2/PGE(2) pathway might also be criti

SUBMITTER: Feng Y 

PROVIDER: S-EPMC3398414 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature