Networks involved in seizure initiation. A reading epilepsy case studied with EEG-fMRI and MEG.

ABSTRACT:

Objective

To define the ictal cortical/subcortical network of reading-induced seizures.

Methods

We analyzed ictal magnetoencephalography (MEG) and EEG-correlated fMRI (EEG-fMRI) data in a unique patient with reading epilepsy (RE) affected by frequent perioral reflex myocloni triggered by reading silently.

Results

Ictal MEG corroborated EEG localization and revealed activity extending precentrally into Brodmann area (BA) 6. fMRI blood oxygen level-dependent (BOLD) signal changes in the left deep piriform cortex (PFC) and left BA6 preceded seizures and occurred before BOLD changes were observed in thalamus and right inferior frontal gyrus (BA44). Dynamic causal modeling provided evidence of a causal link between hemodynamic changes in the left PFC and reading-evoked sei

SUBMITTER: Vaudano AE 

PROVIDER: S-EPMC3398433 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature