Anatomically versus biologically unifocal prostate cancer: a pathological evaluation in the context of focal therapy.

ABSTRACT:

Objectives

Since tumor focality in prostate cancer continues to be considered a major limitation for focal prostate therapy, in this study we attempted to compare the pathological features and the proportion of patients with anatomically unifocal versus biologically unifocal tumors (i.e. multifocal prostate cancer in which the secondary nonindex elements are small, low grade and clinically insignificant) who were suitable for focal therapy.

Methods

Ninety-five consecutive whole mount laparoscopic radical prostatectomy samples underwent pathological assessment (from January 2007 to November 2009). Tumor focality, laterality, Gleason score and volume of individual foci, total tumor volume, pathological stage and surgical margin status were assessed. The index lesion was define

SUBMITTER: Karavitakis M 

PROVIDER: S-EPMC3398599 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature