Facile Synthesis of Mutagen X (MX): 3-Chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one.

ABSTRACT: 3-Chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one (Mutagen X, MX) was synthesized in six steps from commercially-available and inexpensive starting materials (27% overall yield). This synthesis enables the preparation of MX analogs and does not require the use of chlorine gas, as do previously reported methods.

SUBMITTER: Velvadapu V 

PROVIDER: S-EPMC3398704 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature