Reciprocal transcriptional regulation of metabolic and signaling pathways correlates with disease severity in heart failure.

ABSTRACT:

Background

Systolic heart failure (HF) is a complex systemic syndrome that can result from a wide variety of clinical conditions and gene mutations. Despite phenotypic similarities, characterized by ventricular dilatation and reduced contractility, the extent of common and divergent gene expression between different forms of HF remains a matter of intense debate.

Methods and results

Using a meta-analysis of 28 experimental (mouse, rat, dog) and human HF microarray studies, we demonstrate that gene expression changes are characterized by a coordinated and reciprocal regulation of major metabolic and signaling pathways. In response to a wide variety of stressors in animal models of HF, including ischemia, pressure overload, tachypacing, chronic isoproterenol infusion, Chagas d

SUBMITTER: Barth AS 

PROVIDER: S-EPMC3398805 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature