Ontology highlight
ABSTRACT:
SUBMITTER: Coquery N
PROVIDER: S-EPMC3398898 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Coquery Nicolas N Pannetier Nicolas N Farion Régine R Herbette Aurélie A Azurmendi Leire L Clarencon Didier D Bauge Stéphane S Josserand Véronique V Rome Claire C Coll Jean-Luc JL Sun Jian-Sheng JS Barbier Emmanuel L EL Dutreix Marie M Remy Chantal C CC
PloS one 20120717 7
<h4>Background</h4>Glioma is the most aggressive tumor of the brain and the most efficient treatments are based on radiotherapy. However, tumors are often resistant to radiotherapy due to an enhanced DNA repair activity. Short and stabilized DNA molecules (Dbait) have recently been proposed as an efficient strategy to inhibit DNA repair in tumor.<h4>Methodology/principal findings</h4>The distribution of three formulations of Dbait, (i) Dbait alone, (ii) Dbait associated with polyethylenimine, an ...[more]