Complex patterns of human antisera reactivity to novel 2009 H1N1 and historical H1N1 influenza strains.

ABSTRACT:

Background

During the 2009 influenza pandemic, individuals over the age of 60 had the lowest incidence of infection with approximately 25% of these people having pre-existing, cross-reactive antibodies to novel 2009 H1N1 influenza isolates. It was proposed that older people had pre-existing antibodies induced by previous 1918-like virus infection(s) that cross-reacted to novel H1N1 strains.

Methodology/principal findings

Using antisera collected from a cohort of individuals collected before the second wave of novel H1N1 infections, only a minority of individuals with 1918 influenza specific antibodies also demonstrated hemagglutination-inhibition activity against the novel H1N1 influenza. In this study, we examined human antisera collected from individuals that ranged betwee

SUBMITTER: Carter DM 

PROVIDER: S-EPMC3398940 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature