Inferring proteolytic processes from mass spectrometry time series data using degradation graphs.

ABSTRACT:

Background

Proteases play an essential part in a variety of biological processes. Besides their importance under healthy conditions they are also known to have a crucial role in complex diseases like cancer. In recent years, it has been shown that not only the fragments produced by proteases but also their dynamics, especially ex vivo, can serve as biomarkers. But so far, only a few approaches were taken to explicitly model the dynamics of proteolysis in the context of mass spectrometry.

Results

We introduce a new concept to model proteolytic processes, the degradation graph. The degradation graph is an extension of the cleavage graph, a data structure to reconstruct and visualize the proteolytic process. In contrast to previous approaches we extended the model to incorporat

SUBMITTER: Aiche S 

PROVIDER: S-EPMC3398944 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature