Fine scale spatiotemporal clustering of dengue virus transmission in children and Aedes aegypti in rural Thai villages.

ABSTRACT:

Background

Based on spatiotemporal clustering of human dengue virus (DENV) infections, transmission is thought to occur at fine spatiotemporal scales by horizontal transfer of virus between humans and mosquito vectors. To define the dimensions of local transmission and quantify the factors that support it, we examined relationships between infected humans and Aedes aegypti in Thai villages.

Methodology/principal findings

Geographic cluster investigations of 100-meter radius were conducted around DENV-positive and DENV-negative febrile "index" cases (positive and negative clusters, respectively) from a longitudinal cohort study in rural Thailand. Child contacts and Ae. aegypti from cluster houses were assessed for DENV infection. Spatiotemporal, demographic, and entomological

SUBMITTER: Yoon IK 

PROVIDER: S-EPMC3398976 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature