Genetic predictors of fatigue in prostate cancer patients treated with androgen deprivation therapy: preliminary findings.

ABSTRACT:

Background

Fatigue is a common and distressing side effect of androgen deprivation therapy (ADT) for prostate cancer. The goal of the current study was to examine the relationship between changes in fatigue following initiation of ADT and single nucleotide polymorphisms (SNPs) in three pro-inflammatory cytokine genes: interleukin-1 beta (IL1B), interleukin-6 (IL6), and tumor necrosis factor alpha (TNFA).

Methods

As part of a larger study, men with prostate cancer (n = 53) were recruited prior to initiation of ADT. Fatigue was assessed at recruitment and 6 months after initiation of ADT. DNA was extracted from blood drawn at baseline.

Results

Patients with the IL6-174 (rs1800795) G/C or C/C genotype displayed greater increases in fatigue intrusiveness, frequency, and d

SUBMITTER: Jim HS 

PROVIDER: S-EPMC3399038 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature