EGFR-PI3K-AKT-mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy.

ABSTRACT:

Importance of the field

Recent advances in the understanding of the oncogenesis of head and neck squamous cell carcinomas (HNSCC) have revealed multiple dysregulated signaling pathways. One frequently altered axis is the EGFR-PI3K-Akt-mTOR pathway. This pathway plays a central role in numerous cellular processes including metabolism, cell growth, apoptosis, survival and differentiation, which ultimately contributes to HNSCC progression.

Areas covered in this review

Books, journals, databases and websites have been searched to provide a current review on the subject.

What the reader will gain

This article reviews the current understanding of EGFR-PI3K-Akt-mTOR signaling in HNSCC, including the impact of both genetic and epigenetic alterations. This review further highl

SUBMITTER: Freudlsperger C 

PROVIDER: S-EPMC3399735 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature