Epigenetic impact of simulated maternal grooming on estrogen receptor alpha within the developing amygdala.

ABSTRACT: Variations in maternal care alter the developmental programming of some genes by creating lasting differences in DNA methylation patterns, such as the estrogen receptor alpha (ERα) promoter region. Interestingly, mother rats preferentially lick and groom their male offspring more than females; therefore, we questioned whether the somatosensory stimuli associated with maternal grooming influences potential sex differences in DNA methylation patterns within the developing amygdala, an area important for socioemotional processing. We report a sex difference in the DNA methylation pattern of specific CpG sites of the ERα promoter region within the developing amygdala. Specifically, males have higher levels of ERα promoter methylation contrasted to females. Increasing the levels of maternal sti

SUBMITTER: Edelmann MN 

PROVIDER: S-EPMC3399737 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature