Sequence-based polymorphisms in the mitochondrial D-loop and potential SNP predictors for chronic dialysis.

ABSTRACT:

Background

The mitochondrial (mt) displacement loop (D-loop) is known to accumulate structural alterations and mutations. The aim of this study was to investigate the prevalence of single nucleotide polymorphisms (SNPs) within the D-loop among chronic dialysis patients and healthy controls.

Methodology and principal findings

We enrolled 193 chronic dialysis patients and 704 healthy controls. SNPs were identified by large scale D-loop sequencing and bioinformatic analysis. Chronic dialysis patients had lower body mass index, blood thiols, and cholesterol levels than controls. A total of 77 SNPs matched with the positions in reference of the Revised Cambridge Reference Sequence (CRS) were found in the study population. Chronic dialysis patients had a significantly higher incid

SUBMITTER: Chen JB 

PROVIDER: S-EPMC3399812 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature