Association between the ERCC5 Asp1104His polymorphism and cancer risk: a meta-analysis.

ABSTRACT:

Background

Excision repair cross complementing group 5 (ERCC5 or XPG) plays an important role in regulating DNA excision repair, removal of bulky lesions caused by environmental chemicals or UV light. Mutations in this gene cause a rare autosomal recessive syndrome, and its functional single nucleotide polymorphisms (SNPs) may alter DNA repair capacity phenotype and cancer risk. However, a series of epidemiological studies on the association between the ERCC5 Asp1104His polymorphism (rs17655, G>C) and cancer susceptibility generated conflicting results.

Methodology/principal findings

To derive a more precise estimation of the association between the ERCC5 Asp1104His polymorphism and overall cancer risk, we performed a meta-analysis of 44 published case-control studies, in wh

SUBMITTER: Zhu ML 

PROVIDER: S-EPMC3399856 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature