ILF-3 is a regulator of the neural plate border marker Zic1 in chick embryos.

ABSTRACT:

Background

The neural crest is a multipotent cell type unique to the vertebrate lineage and capable of differentiating into a large number of varied cell types, including ganglia of the peripheral nervous system, cartilage, and glia. An early step in neural crest specification occurs at the neural plate border, a region defined by the overlap of transcription factors of the Zic, Msx, and Pax families.

Results

Here we identify a novel chick gene with close homology to double-stranded RNA-binding protein Interleukin enhancer binding factor 3 (ILF-3) in other species. Our results show that chick Ilf-3 is required for proper expression of the transcription factor, Zic-1, at the neural plate border.

Conclusion

We have identified a novel chick gene and show it has a role in

SUBMITTER: Fishwick KJ 

PROVIDER: S-EPMC3399927 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature