Accuracy of a GFR estimating equation over time in people with a wide range of kidney function.

ABSTRACT:

Background

Change in glomerular filtration rate (GFR) is important for clinical decision making. GFR estimates from serum creatinine level provide an unbiased but imprecise estimate of GFR at single time points. However, the accuracy of estimated GFR over time is not well known.

Study design

Longitudinal study of diagnostic test accuracy.

Settings & participants

4 clinical trials with longitudinal measurements of GFR and serum creatinine on the same day, including individuals with and without kidney disease with a wide range of kidney function, diverse racial backgrounds, and varied clinical characteristics.

Index test

GFR estimated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation.

Reference test

GFR measured using urinary c

SUBMITTER: Padala S 

PROVIDER: S-EPMC3399947 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature