Audiology in the sudden hearing loss clinical trial.

ABSTRACT:

Objective

To report the pretreatment and posttreatment population characteristics and the overall stability of the audiologic outcomes found during the Sudden Hearing Loss Clinical Trial (ClinicalTrials.gov: Identifier NCT00097448).

Study design

Multicenter, prospective randomized noninferiority trial of oral versus intratympanic (IT) steroid treatment of sudden sensorineural hearing loss (SSNHL).

Setting

Fifteen academically based otology practices.

Patients

Two hundred fifty patients with unilateral SSNHL presenting within 14 days of onset with 50 dBHL or greater pure tone average hearing threshold in the affected ear.

Intervention

Either 60 mg/d oral prednisone for 14 days with a 5-day taper (121 patients) or 4 IT doses for 14 days of 40 mg/ml methylp

SUBMITTER: Halpin C 

PROVIDER: S-EPMC3400088 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature