Role of the transient outward potassium current in the genesis of early afterdepolarizations in cardiac cells.

ABSTRACT:

Aims

The transient outward potassium current (I(to)) plays important roles in action potential (AP) morphology and dynamics; however, its role in the genesis of early afterdepolarizations (EADs) is not well understood. We aimed to study the effects and mechanisms of I(to) on EAD genesis in cardiac cells using combined experimental and computational approaches.

Methods and results

We first carried out patch-clamp experiments in isolated rabbit ventricular myocytes exposed to H(2)O(2) (0.2 or 1 mM), in which EADs were induced at a slow pacing rate. EADs were eliminated by either increasing the pacing rate or blocking I(to) with 2 mM 4-aminopyridine. In addition to enhancing the L-type calcium current (I(Ca,L)) and the late sodium current, H(2)O(2) also increased the conductanc

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC3400356 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature