A twin association study of nicotine dependence with markers in the CHRNA3 and CHRNA5 genes.

ABSTRACT: Twin and family studies have provided overwhelming evidence for the genetic basis of individual differences in tobacco initiation (TI), regular smoking (RS) and nicotine dependence (ND). However, only a few genes have been reliably associated with ND. We used a finite mixture distribution model to examine the significance and effect size of the association of previously identified and replicated specific variants in the CHRNA5 and CHRNA3 receptor genes with ND, against the background of genetic and environmental risk factors for ND. We hypothesize that additional phenotypic information in relatives who have not been genotyped can be used to increase the power of detecting the genetic variant. The nicotine measures were assessed by personal interview in female, male and opposite sex twin pa

SUBMITTER: Maes HH 

PROVIDER: S-EPMC3400498 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature