Mallory-Denk bodies are associated with outcomes and histologic features in patients with chronic hepatitis C.

ABSTRACT:

Background & aims

Mallory-Denk bodies (MDBs) are inclusions found in hepatocytes of patients with chronic liver diseases. Their clinical significance and prognostic value are not understood.

Methods

We performed cross-sectional and longitudinal analyses of patients with chronic hepatitis C (CHC) enrolled in the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis (HALT-C) trial to identify clinical features associated with MDBs and changes in MDBs over time. Biopsy specimens were obtained at baseline and 1.5 and 3.5 years after patients were assigned to groups for the HALT-C trial; and patients were followed up to assess clinical and histologic outcomes.

Results

Of biopsy samples collected from 1050 patients, MDBs were present in 15%. They were associated with

SUBMITTER: Rakoski MO 

PROVIDER: S-EPMC3400531 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature