Diastereoselective chelation-controlled additions to β-silyloxy aldehydes.

ABSTRACT: A general diastereoselective method for the addition of dialkylzincs and (E)-di- and (E)-trisubstituted vinylzinc reagents to β-silyloxy aldehydes is presented. This method employs alkyl zinc triflate and nonaflate Lewis acids and affords chelation-controlled products (6:1 to > 20:1 dr).

SUBMITTER: Stanton GR 

PROVIDER: S-EPMC3401491 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature