Clinical correlates of white matter tract degeneration in progressive supranuclear palsy.

ABSTRACT:

Objectives

To use diffusion tensor imaging to assess white matter tract degeneration in progressive supranuclear palsy (PSP) and to investigate correlates between tract integrity and clinical measures.

Design

Case-control study.

Setting

Tertiary care medical center.

Patients/participants

Twenty patients with probable PSP and 20 age- and sex-matched healthy controls were enrolled. All patients with PSP underwent standardized clinical testing, including the Frontal Behavioral Inventory and Frontal Assessment Battery to assess behavioral change, the PSP Rating Scale to measure disease severity, the Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (parts II and III) to measure motor function, and the PSP Saccadic Impairme

SUBMITTER: Whitwell JL 

PROVIDER: S-EPMC3401587 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature