Footprints of genetic susceptibility to pulmonary tuberculosis: cytokine gene variants in north Indians.

ABSTRACT:

Background & objectives

Tuberculosis is (TB) responsible for high morbidity and mortality worldwide. Cytokines play a major role in defense against Mycobacterium tuberculosis infection. Polymorphisms in the genes encoding the various pro- and anti-inflammatory cytokines have been associated with tuberculosis susceptibility. In this study we examined association of 25 sequence polymorphisms in six candidate cytokine genes namely IFNG, TNFB, IL4, IL1RA, IL1B and IL12 and their related haplotypes with risk of developing pulmonary tuberculosis (PTB) among north Indians.

Methods

Pulmonary TB (n=110) patients and 215 healthy controls (HC) from north India were genotyped. Purified multiplex PCR products were subjected to mass spectrometry using Sequenom MassARRAY platform to genera

SUBMITTER: Abhimanyu 

PROVIDER: S-EPMC3401711 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature