Antiemetic treatment for acute gastroenteritis in children: an updated Cochrane systematic review with meta-analysis and mixed treatment comparison in a Bayesian framework.

ABSTRACT:

Objective

To assess the evidence for the safety and effectiveness of antiemetics on gastroenteritis-induced vomiting in children and adolescents.

Design

Systematic review.

Data sources

The Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE searched from 1980 to March 2012.

Methods

Methods included comprehensive searches, data synthesis, meta-analysis and mixed treatment comparisons (MTC).

Review methods

Reference lists were checked, and missing or inconsistent data were sought from trial investigators. Randomised controlled trials comparing antiemetics in participants younger than 18 years and who were vomiting due to acute gastroenteritis. Four meta-analyses and three MTC were carried out.

Results

10 trials (1479 participants) and

SUBMITTER: Carter B 

PROVIDER: S-EPMC3401831 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature