Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia.

ABSTRACT:

Objective

Published studies suggest associations between circadian gene polymorphisms and bipolar I disorder (BPI), as well as schizoaffective disorder (SZA) and schizophrenia (SZ). The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders.

Methods

We assayed 276 publicly available 'tag' single nucleotide polymorphisms (SNPs) at 21 circadian genes among 523 patients with BPI, 527 patients with SZ/SZA, and 477 screened adult controls. Detected associations were evaluated in relation to two published genome-wide association studies (GWAS).

Results

Using gene-based tests, suggestive associations were noted between EGR3 and BPI (p

SUBMITTER: Mansour HA 

PROVIDER: S-EPMC3401899 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature