Gene Expression Profiling in Hereditary, BRCA1-linked Breast Cancer: Preliminary Report.

ABSTRACT: Global analysis of gene expression by DNA microarrays is nowadays a widely used tool, especially relevant for cancer research. It helps the understanding of complex biology of cancer tissue, allows identification of novel molecular markers, reveals previously unknown molecular subtypes of cancer that differ by clinical features like drug susceptibility or general prognosis. Our aim was to compare gene expression profiles in breast cancer that develop against a background of inherited predisposing mutations versus sporadic breast cancer. In this preliminary study we analysed seven hereditary, BRCA1 mutation-linked breast cancer tissues and seven sporadic cases that were carefully matched by histopathology and ER status. Additionally, we analysed 6 samples of normal breast tissue. We found t

SUBMITTER: Dudaladava V 

PROVIDER: S-EPMC3401917 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature