Role of muscle mass and muscle quality in the association between diabetes and gait speed.

ABSTRACT:

Objective

Older people with type 2 diabetes are at high risk of mobility disability. We investigated the association of diabetes with lower-limb muscle mass and muscle quality to verify whether diabetes-related muscle impairments mediate the association between diabetes and low walking speed.

Research design and methods

We performed a cross-sectional analysis of 835 participants (65 years old and older) enrolled in the InCHIANTI (Invecchiare in Chianti, aging in the Chianti area) population-based study. Total, muscular, and fat cross-sectional areas of the calf and relative muscle density were measured using peripheral quantitative computerized tomography. Indicators of muscle performance included knee-extension torque, ankle plantar flexion and dorsiflexion strength, lower-

SUBMITTER: Volpato S 

PROVIDER: S-EPMC3402248 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature