Transgenic control of mitochondrial fission induces mitochondrial uncoupling and relieves diabetic oxidative stress.

ABSTRACT: Mitochondria are the essential eukaryotic organelles that produce most cellular energy. The energy production and supply by mitochondria appear closely associated with the continuous shape change of mitochondria mediated by fission and fusion, as evidenced not only by the hereditary diseases caused by mutations in fission/fusion genes but also by aberrant mitochondrial morphologies associated with numerous pathologic insults. However, how morphological change of mitochondria is linked to their energy-producing activity is poorly understood. In this study, we found that perturbation of mitochondrial fission induces a unique mitochondrial uncoupling phenomenon through a large-scale fluctuation of a mitochondrial inner membrane potential. Furthermore, by genetically controlling mitochondrial

SUBMITTER: Galloway CA 

PROVIDER: S-EPMC3402299 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature