Association of MDM2 SNP309 variation with lung cancer risk: evidence from 7196 cases and 8456 controls.

ABSTRACT:

Background

Evidence suggests that MDM2 T309G polymorphism may be a risk factor for several cancers. Increasing investigations have been conducted on the association of MDM2 T309G polymorphisms with lung cancer risk and have yielded conflicting results. Previous meta-analyses on this issue have reported inconclusive data. The aim of the present study was to derive a more precise estimation of the relationship.

Methods and findings

Updated meta-analyses examining the association between MDM2 T309G polymorphism and lung cancer risk were performed. Separate analyses on ethnicity, smoking status, histological types and gender as well as source of controls were also implemented. Eligible studies were identified for the period up to Feb 2012. Lastly, ten publications including elev

SUBMITTER: Zhuo W 

PROVIDER: S-EPMC3402389 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature