Local oxidative stress expansion through endothelial cells--a key role for gap junction intercellular communication.

ABSTRACT:

Background

Major circulation pathologies are initiated by oxidative insult expansion from a few injured endothelial cells to distal sites; this possibly involves mechanisms that are important to understanding circulation physiology and designing therapeutic management of myocardial pathologies. We tested the hypothesis that a localized oxidative insult of endothelial cells (ECs) propagates through gap junction inter-cellular communication (GJIC).

Methodology/principal findings

Cultures comprising the bEnd.3 cell line, that have been established and recognized as suitable for examining communication among ECs, were used to study the propagation of a localized oxidative insult to remote cells. Spatially confined near infrared illumination of parental or genetically modified bE

SUBMITTER: Feine I 

PROVIDER: S-EPMC3402439 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature