Long-term relationships between cholinergic tone, synchronous bursting and synaptic remodeling.

ABSTRACT: Cholinergic neuromodulation plays key roles in the regulation of neuronal excitability, network activity, arousal, and behavior. On longer time scales, cholinergic systems play essential roles in cortical development, maturation, and plasticity. Presumably, these processes are associated with substantial synaptic remodeling, yet to date, long-term relationships between cholinergic tone and synaptic remodeling remain largely unknown. Here we used automated microscopy combined with multielectrode array recordings to study long-term relationships between cholinergic tone, excitatory synapse remodeling, and network activity characteristics in networks of cortical neurons grown on multielectrode array substrates. Experimental elevations of cholinergic tone led to the abrupt suppression of episo

SUBMITTER: Kaufman M 

PROVIDER: S-EPMC3402441 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature