Evidence of associations between cytokine genes and subjective reports of sleep disturbance in oncology patients and their family caregivers.

ABSTRACT: The purposes of this study were to identify distinct latent classes of individuals based on subjective reports of sleep disturbance; to examine differences in demographic, clinical, and symptom characteristics between the latent classes; and to evaluate for variations in pro- and anti-inflammatory cytokine genes between the latent classes. Among 167 oncology outpatients with breast, prostate, lung, or brain cancer and 85 of their FCs, growth mixture modeling (GMM) was used to identify latent classes of individuals based on General Sleep Disturbance Scale (GSDS) obtained prior to, during, and for four months following completion of radiation therapy. Single nucleotide polymorphisms (SNPs) and haplotypes in candidate cytokine genes were interrogated for differences between the two latent cla

SUBMITTER: Miaskowski C 

PROVIDER: S-EPMC3402493 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature