Identifying protein phosphorylation sites with kinase substrate specificity on human viruses.

ABSTRACT: Viruses infect humans and progress inside the body leading to various diseases and complications. The phosphorylation of viral proteins catalyzed by host kinases plays crucial regulatory roles in enhancing replication and inhibition of normal host-cell functions. Due to its biological importance, there is a desire to identify the protein phosphorylation sites on human viruses. However, the use of mass spectrometry-based experiments is proven to be expensive and labor-intensive. Furthermore, previous studies which have identified phosphorylation sites in human viruses do not include the investigation of the responsible kinases. Thus, we are motivated to propose a new method to identify protein phosphorylation sites with its kinase substrate specificity on human viruses. The experimentally v

SUBMITTER: Bretana NA 

PROVIDER: S-EPMC3402495 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature