Histopathology of naturally occurring and surgically induced osteoarthritis in mice.

ABSTRACT:

Objective

The morphology of lesions in mouse models of osteoarthritis (OA) has not been comprehensively characterized, in part because current histological assessments of OA focus primarily on articular cartilage (AC). In the present study, sections of murine stifle joints with naturally occurring (aged animals) and surgically induced (destabilized medial meniscus, DMM) OA were examined using a newly developed histological grading scheme that includes quantitative measurements and semiquantitative grades to evaluate multiple joint tissues.

Design

The data collected was analyzed using Principal Components Analysis (PCA); factor scores for each joint were generated. Individual parameters and factor scores were compared between surgical groups and among age groups. For comparis

SUBMITTER: McNulty MA 

PROVIDER: S-EPMC3402508 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature