Oscillatory cortical network involved in auditory verbal hallucinations in schizophrenia.

ABSTRACT:

Background

Auditory verbal hallucinations (AVH), a prominent symptom of schizophrenia, are often highly distressing for patients. Better understanding of the pathogenesis of hallucinations could increase therapeutic options. Magnetoencephalography (MEG) provides direct measures of neuronal activity and has an excellent temporal resolution, offering a unique opportunity to study AVH pathophysiology.

Methods

Twelve patients (10 paranoid schizophrenia, 2 psychosis not otherwise specified) indicated the presence of AVH by button-press while lying in a MEG scanner. As a control condition, patients performed a self-paced button-press task. AVH-state and non-AVH state were contrasted in a region-of-interest (ROI) approach. In addition, the two seconds before AVH onset were contrast

SUBMITTER: van Lutterveld R 

PROVIDER: S-EPMC3402538 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature