Inhibitory effects of pirfenidone on dendritic cells and lung allograft rejection.

ABSTRACT:

Background

Pirfenidone (PFD) is an antifibrotic agent with beneficial effects on proinflammatory disorders. In this study, we further investigated PFD and long-acting form, "deuterated PFD," immune-modulating properties by evaluating their effects on mouse dendritic cells (DCs).

Methods

The effects of PFD on DCs were examined in vivo using an orthotopic mouse lung transplant model and in vitro using isolated bone marrow-derived DCs in response to lipopolysaccharide and allogeneic stimulation.

Results

In mouse lung transplants, PFD and deuterated PFD treatment improved allograft lung function based on peak airway pressure, less infiltrates/consolidation on micro-computed tomography scan imaging, and reduced lung rejection/injury. DC activation from lung allografts was

SUBMITTER: Bizargity P 

PROVIDER: S-EPMC3402635 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature