Ontology highlight
ABSTRACT:
SUBMITTER: Ishigaki S
PROVIDER: S-EPMC3402842 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Scientific reports 20120724
FUS is an RNA-binding protein that regulates transcription, alternative splicing, and mRNA transport. Aberrations of FUS are causally associated with familial and sporadic ALS/FTLD. We analyzed FUS-mediated transcriptions and alternative splicing events in mouse primary cortical neurons using exon arrays. We also characterized FUS-binding RNA sites in the mouse cerebrum with HITS-CLIP. We found that FUS-binding sites tend to form stable secondary structures. Analysis of position-dependence of FU ...[more]