Polymorphic variation in choline transporter gene (CHT1) is associated with early, subclinical measures of carotid atherosclerosis in humans.
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ABSTRACT:
SUBMITTER: Neumann SA
PROVIDER: S-EPMC3403193 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
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Polymorphic variation in choline transporter gene (CHT1) is associated with early, subclinical measures of carotid atherosclerosis in humans.
Neumann Serina A SA Linder Katherine J KJ Muldoon Matthew F MF Sutton-Tyrrell Kimberly K Kline Christopher C Shrader Catherine J CJ Lawrence Elizabeth C EC Ferrell Robert E RE Manuck Stephen B SB
The international journal of cardiovascular imaging 20110220 2
Atherosclerosis is a heritable trait with little known about specific genetic influences on preclinical measures of plaque formation. Based on relations of parasympathetic-cholinergic function to atherosclerosis and to a choline transporter gene [CHT1 (G/T)] polymorphism, we investigated whether the same allelic variant predicts variation in carotid intima-media thickness (IMT) and plaque formation. Carotid IMT and plaque occurrence as well as genotyping for the CHT1 (G/T) variant were measured ...[more]
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