The preservation of bidirectional promoter architecture in eukaryotes: what is the driving force?

ABSTRACT:

Background

The bidirectional gene architecture has been studied in many organisms, and the conservation of bidirectional arrangement has received considerable attention. However, the explanation for the evolutionary conservation about this genomic structure is still insufficient. In this study the large scale identification and pathway enrichment analysis for bidirectional genes were performed in several eukaryotes and the comparative analysis of this arrangement between human and mouse were dissected for the purpose of discovering the driving force of the preservation of this genomic structure.

Results

We identified the bidirectional gene pairs in eight different species and found this structure to be prevalent in eukaryotes. The pathway enrichment analysis indicated the bi

SUBMITTER: Xu C 

PROVIDER: S-EPMC3403606 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature