Insights into the pathogenesis of axial spondyloarthropathy from network and pathway analysis.

ABSTRACT:

Background

Complex chronic diseases are usually not caused by changes in a single causal gene but by an unbalanced regulating network resulting from the dysfunctions of multiple genes or their products. Therefore, network based systems approach can be helpful for the identification of candidate genes related to complex diseases and their relationships. Axial spondyloarthropathy (SpA) is a group of chronic inflammatory joint diseases that mainly affect the spine and the sacroiliac joints. The pathogenesis of SpA remains largely unknown.

Results

In this paper, we conducted a network study of the pathogenesis of SpA. We integrated data related to SpA, from the OMIM database, proteomics and microarray experiments of SpA, to prioritize SpA candidate disease genes in the context o

SUBMITTER: Zhao J 

PROVIDER: S-EPMC3403611 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature