Nitric oxide for inhalation in the acute treatment of sickle cell pain crisis: a randomized controlled trial.

ABSTRACT:

Context

Inhaled nitric oxide has shown evidence of efficacy in mouse models of sickle cell disease (SCD), case series of patients with acute chest syndrome, and 2 small placebo-controlled trials for treatment of vaso-occlusive pain crisis (VOC).

Objective

To determine whether inhaled nitric oxide gas reduces the duration of painful crisis in patients with SCD who present to the emergency department or hospital for care.

Design, setting, and participants

Prospective, multicenter, double-blind, randomized, placebo-controlled clinical trial for up to 72 hours of inhaled nitric oxide gas vs inhaled nitrogen placebo in 150 participants presenting with VOC of SCD at 11 centers between October 5, 2004, and December 22, 2008. Intervention Inhaled nitric oxide gas vs inhaled n

SUBMITTER: Gladwin MT 

PROVIDER: S-EPMC3403835 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature