Age-dependent kinetics of dentate gyrus neurogenesis in the absence of cyclin D2.

ABSTRACT:

Background

Adult neurogenesis continuously adds new neurons to the dentate gyrus and the olfactory bulb. It involves the proliferation and subsequent differentiation of neuronal progenitors, and is thus closely linked to the cell cycle machinery. Cell cycle progression is governed by the successive expression, activation and degradation of regulatory proteins. Among them, D-type cyclins control the exit from the G1 phase of the cell cycle. Cyclin D2 (cD2) has been shown to be required for the generation of new neurons in the neurogenic niches of the adult brain. It is differentially expressed during hippocampal development, and adult cD2 knock out (cD2KO) mice virtually lack neurogenesis in the dentate gyrus and olfactory bulb. In the present study we examined the dynamics of postn

SUBMITTER: Ansorg A 

PROVIDER: S-EPMC3403990 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature