Frontal asymmetry in behavioral variant frontotemporal dementia: clinicoimaging and pathogenetic correlates.

ABSTRACT: We aimed to assess associations between clinical, imaging, pathologic, and genetic features and frontal lobe asymmetry in behavioral variant frontotemporal dementia (bvFTD). Volumes of the left and right dorsolateral, medial, and orbital frontal lobes were measured in 80 bvFTD subjects and subjects were classified into 3 groups according to the degree of asymmetry (asymmetric left, asymmetric right, symmetric) using cluster analysis. The majority of subjects were symmetric (65%), with 20% asymmetric left and 15% asymmetric right. There were no clinical differences across groups, although there was a trend for greater behavioral dyscontrol in right asymmetric compared with left asymmetric subjects. More widespread atrophy involving the parietal lobe was observed in the symmetric group. Gene

SUBMITTER: Whitwell JL 

PROVIDER: S-EPMC3404265 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature