Lactobacillus-mediated priming of the respiratory mucosa protects against lethal pneumovirus infection.

ABSTRACT: The inflammatory response to respiratory virus infection can be complex and refractory to standard therapy. Lactobacilli, when targeted to the respiratory epithelium, are highly effective at suppressing virus-induced inflammation and protecting against lethal disease. Specifically, wild-type mice primed via intranasal inoculation with live or heat-inactivated Lactobacillus plantarum or Lactobacillus reuteri were completely protected against lethal infection with the virulent rodent pathogen, pneumonia virus of mice; significant protection (60% survival) persisted for at least 13 wk. Protection was not unique to Lactobacillus species, and it was also observed in response to priming with nonpathogenic Gram-positive Listeria innocua. Priming with live lactobacilli resulted in diminished granu

SUBMITTER: Gabryszewski SJ 

PROVIDER: S-EPMC3404433 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature