Haemoglobinopathies and the clinical epidemiology of malaria: a systematic review and meta-analysis.

ABSTRACT:

Background

Haemoglobinopathies can reduce the risk of malaria syndromes. We aimed to quantify the relation between different haemoglobin mutations and malaria protection to strengthen the foundation for translational studies of malaria pathogenesis and immunity.

Methods

We systematically searched the Medline and Embase databases for studies that estimated the risk of malaria in patients with and without haemoglobinopathies up to Sept 9, 2011, and identified additional studies from reference lists. We included studies that enrolled mainly children or pregnant women and had the following outcomes: Plasmodium falciparum severe malaria, uncomplicated malaria, asymptomatic parasitaemia, or pregnancy-associated malaria, and Plasmodium vivax malaria. Two reviewers identified studie

SUBMITTER: Taylor SM 

PROVIDER: S-EPMC3404513 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature