Biosensor zebrafish provide new insights into potential health effects of environmental estrogens.

ABSTRACT:

Background

Environmental estrogens alter hormone signaling in the body that can induce reproductive abnormalities in both humans and wildlife. Available testing systems for estrogens are focused on specific systems such as reproduction. Crucially, however, the potential for significant health impacts of environmental estrogen exposures on a variety of body systems may have been overlooked.

Objective

Our aim was to develop and apply a sensitive transgenic zebrafish model to assess real-time effects of environmental estrogens on signaling mechanisms in a whole body system for use in integrated health assessments.

Methods

We created a novel transgenic biosensor zebrafish containing an estrogen-inducible promoter derived with multiple tandem estrogen responsive elements (

SUBMITTER: Lee O 

PROVIDER: S-EPMC3404660 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature