Associations of prenatal exposure to organophosphate pesticide metabolites with gestational age and birth weight.

ABSTRACT:

Background

Prenatal exposure to organophosphate (OP) insecticides, a widely used class of pesticides, may be associated with decreased gestational age and lower birth weight. Single nucleotide polymorphisms in paroxanase (PON1) enzyme genotypes may modify the relationships between OP exposure and perinatal outcomes.

Objective

We examined the relationship of prenatal OP insecticide exposure, measured using urinary dialkyl phosphate (DAP) metabolite concentrations, with gestational age and birth weight.

Methods

We measured the concentrations of six nonspecific DAP metabolites of OP insecticides in two maternal spot urine samples collected in a prospective birth cohort. We performed multivariable regression to examine associations between the sum of six DAP concentration

SUBMITTER: Rauch SA 

PROVIDER: S-EPMC3404666 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature