Imatinib-induced liver cirrhosis in a patient with advanced gastrointestinal stroma tumor (GIST).

ABSTRACT:

Background

The use of imatinib mesylate is associated with a progression free survival of 41 months in first line treatment of metastatic or locally advanced gastrointestinal stromal tumors (GIST) and other studies approved that adjuvant imatinib treatment improves the recurrence-free survival in patients with GIST. Current recommendations include 1 year adjuvant treatment in GIST patients at risk but active studies explore different durations of treatment with an interval of up to 5 years. While the most frequent adverse events (AEs) are blood count alterations, abdominal discomfort and edema, the occurrence of grade 3 or 4 increase of AST or ALT is specified with 2.1% and 2.7% respectively.

Case presentation

We report a 49-year old male with a gastrointestinal stromal tumo

SUBMITTER: Seidel C 

PROVIDER: S-EPMC3404905 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature