Identification of pathway deregulation--gene expression based analysis of consistent signal transduction.

ABSTRACT: Signaling pathways belong to a complex system of communication that governs cellular processes. They represent signal transduction from an extracellular stimulus via a receptor to intracellular mediators, as well as intracellular interactions. Perturbations in signaling cascade often lead to detrimental changes in cell function and cause many diseases, including cancer. Identification of deregulated pathways may advance the understanding of complex diseases and lead to improvement of therapeutic strategies. We propose Analysis of Consistent Signal Transduction (ACST), a novel method for analysis of signaling pathways. Our method incorporates information regarding pathway topology, as well as data on the position of every gene in each pathway. To preserve gene-gene interactions we use a sub

SUBMITTER: Mieczkowski J 

PROVIDER: S-EPMC3405133 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature