Spatial patterns of water diffusion along white matter tracts in temporal lobe epilepsy.

ABSTRACT:

Objectives

Diffusion tensor imaging (DTI) tractography has shown tract-specific pathology in temporal lobe epilepsy (TLE). This technique normally yields a single value per diffusion parameter per tract, potentially reducing the sensitivity for the detection of focal changes. Our goal was to spatially characterize diffusion abnormalities of fasciculi carrying temporal lobe connections.

Methods

We studied 30 patients with drug-resistant TLE and 21 healthy control subjects. Twenty-four patients underwent DTI toward the end of video-EEG telemetry, with an average of 50 ± 54 hours between the last seizure and DTI examination. After manual dissection of the uncinate and inferior longitudinal and arcuate bundle, they were spatially matched based on their distance to the temporal l

SUBMITTER: Concha L 

PROVIDER: S-EPMC3405250 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature